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KMID : 0043319980210010070
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Archives of Pharmacal Research
1998 Volume.21 No. 1 p.70 ~ p.72
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Total Synthesis of Fentanyl
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Suh Young-Ger
Cho Kyung-Ho
Shin Dong-Yun
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Abstract
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Fentanyl of a potent anilidopiperidine analgesic has been synthesized from a simple phenyle-thylamine by four step sequence. The key part of this synthesis involves an efficient construc-tion of phenylethylpiperidone skeleton via aminomethano desilyation-cyclization followed by Swern oxidation.
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KEYWORD
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Fentanyl, Anagesics, Piperidine, Aminomerthano desilyltion-cyclization
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